| 摘要 |
PROBLEM TO BE SOLVED: To provide a sirtuin derivative using hyaluronic acid oligosaccharide.SOLUTION: A sirtuin derivative contains, as an active ingredient, a combination of at least one kind of hyaluronic acid oligosaccharide selected from a size of 2 sugars or more to 5 sugars or less and a polyphenol. This sirtuin derivative is used for aging suppression, keratinocyte barrier functional promotion, or used for treatment and/or prevention of heart disease, arteriosclerosis, osteoporosis, inflammatory enteritis, dementia, cerebral apoplexy, metabolic syndrome, cancer, lung disease, renal disease, diabetes, osteoarthritis, rheumatism, progeria, radiation injury, myopathy, brain developmental disease, diseases of the nervous system, hypertension, or obesity. |
