CD105-NEGATIVE MULTIPOTENT MESENCHYMAL STROMAL CELLS

摘要

The present patent describes a method based on expression of CD105 that allow the isolation and maintenance of MSCs with improved immunomodulatory and differentiation properties. In this sense, the authors of the present invention show for the first time that CD105- MSCs represent a distinct multipotent MSCs population. They have simitar growth potential and maintain identical MSCs markers than CD105+ MSCs. However CD105-MSCs are better at T cell suppression and more prone to differentiate into adipocytes and osteocytes than CD105+ MSCs. We herein propose the use of this expandable, multipotent CD105- MSCs as an alternative to CD105+ and/or total MSCs for the treatment of autoimmune diseases and bone-related disorders.