<p>The present disclosure provides methods of that include detecting in a biological sample from a patient having or suspected of having cancer the presence of a polypeptide having ROS1 kinase activity or a polynucleotide encoding the same and detecting in the biological sample the presence of a mutant EGFR polypeptide or a polynucleotide encoding the same. In some aspects, the disclosure provides methods of treating a patient for cancer that include determining that a biological sample from a tumor in the patient includes a polypeptide having ROS1 kinase activity or a polynucleotide encoding the same and a mutant EGFR polypeptide or a polynucleotide encoding the same and administering to the patient a therapeutically effective amount of a ROS1 inhibitor and an EGFR inhibitor, thereby treating the patient for cancer.</p>
申请公布号
EP2838998(A1)
申请公布日期
2015.02.25
申请号
EP20130778278
申请日期
2013.04.18
申请人
CELL SIGNALING TECHNOLOGY, INC.
发明人
CROSBY, KATHERINE, ELEANOR;MCGUINNESS RIMKUNAS, VICTORIA;SILVER, MATTHEW, REN;HAACK, HERBERT