HALOGENATED DIDEOXY SACCHARIDE DERIVATIVES, PREPARATION METHOD AND USE THEREOF

摘要

The current invention is related to a halogenated dideoxy sugar derivative, wherein that the derivative has the following general structure I
wherein X is halogen,
or
R 1 and R 2 are H or Br; R 3 and R 4 are OH or OAc. The compounds 1-14 of the current invention has strong inhibition effect on human nasopharyngeal cancer CNE-2Z cells, human lung cancer A549 cells. human colon cancer HT-29 cells, human liver cancer Bel-7402 cells, human rectum cancer cells HCE 8693, human stomach cancer BGC-803 cells, human esophagus cancer CaEs-17 cells, human breast cancer cells MCF-7, human ovarian cancer cells A2780, pancreatic cancer cells PC-3, human bladder cells EJ, human brain glia cells TG-905, human leukemia cells K562, human melanoma M 14 cells and human anaplastic thyroid carcinoma TA-K cells. They can be used to prepare anti-tumor medicament and have significant clinic value.