Sustained release intraocular implants and related methods

摘要

Biocompatible intraocular implants include a steroid and a polymer associated with each other to facilitate release of the steroid into an eye for a period of time greater than about two months. The steroid may be associated with a biodegradable polymer matrix, such as a matrix of a two biodegradable polymers. Or, the steroid may be associated with a polymeric coating having one or more openings effective to permit the steroid to be released into an external environment. The implants may be placed in an eye to treat one or more ocular conditions. The steroid is released from the implant for more than about two months, and may be release for more than several years.

主权项

1. An intraocular implant, comprising:
a polymeric layer covering a core containing a steroid, the polymeric layer including a plurality of holes sized to permit a liquid to pass therethrough, and to permit the steroid to pass from the implant to an external environment at a rate of less than 2 μg/day for a period of time at least about 2 months after the implant is placed in an eye of a patient, wherein each of the holes has a diameter from about 250 μm to about 500 μm.