发明名称 Anticancer steroidal lactones unsaturated in position 7 (8)
摘要 A compound of general formula (I), wherein R1-R17 and the - - - - - - line take various meanings for use in the treatment of cancer.;
申请公布号 US8962602(B2) 申请公布日期 2015.02.24
申请号 US201113642910 申请日期 2011.04.26
申请人 Pharma Mar, S.A. 发明人 Fernández Rodríguez Rogelio;Reyes Benítez José Fernando;Francesch Solloso Andrés;Cuevas Marchante María del Carmen
分类号 A61K31/585;C07J19/00;C07J71/00 主分类号 A61K31/585
代理机构 King & Spalding LLP 代理人 Sonnenfeld Kenneth H.;King & Spalding LLP
主权项 1. A purified compound of general formula I wherein each R1 and R2 is independently selected from hydrogen, halogen, ORa, OCORa, and OCOORa, or R1 and R2 together are ═O; each R3, R15, and R16 is independently selected from hydrogen, ORa, OCORa, OCOORa, and ═O, with the proviso that when a ═O group exists the hydrogen of the C atom to which the ═O is attached is absent; each R4, R5, R6, R7, R11, R12, and R14 is independently selected from hydrogen, ORa, OCORa, and OCOORa; each R8, R9, and R17 is independently selected from hydrogen, ORa, OCORa, OCOORa, substituted or unsubstituted C1-C12 alkyl, substituted or unsubstituted C2-C12 alkenyl, and substituted or unsubstituted C2-C12 alkynyl; R10 is selected from hydrogen, ORb, OCORa, OCOORa, and ═O, with the proviso that when a ═O group exists the hydrogen of the C atom to which the ═O is attached is absent; R13 is selected from hydrogen, CORa, substituted or unsubstituted C1-C12 alkyl, substituted or unsubstituted C2-C12 alkenyl, and substituted or unsubstituted C2-C12 alkynyl; each Ra is independently selected from hydrogen, substituted or unsubstituted C1-C12 alkyl, substituted or unsubstituted C2-C12 alkenyl, substituted or unsubstituted C2-C12 alkynyl, substituted or unsubstituted aryl, and substituted or unsubstituted heterocyclic group; each Rb is independently selected from hydrogen, substituted or unsubstituted C1-C12 alkyl, substituted or unsubstituted C2-C12 alkenyl, substituted or unsubstituted C2-C12 alkynyl, substituted or unsubstituted aryl, substituted or unsubstituted heterocyclic group, and substituted or unsubstituted sugar; and the - - - - - - - line represents an additional bond, an epoxy group, or is absent; or a pharmaceutically acceptable salt, prodrug or stereoisomer thereof.
地址 Madrid ES