| 主权项 |
1. A compound of formula I: wherein substituents A, Q, X, R1, R2, R3, V and W in Formula I are defined as follows: A is one of the following: i) N(R4)(CH2)n where n is 0<n<3 ii) O(CH2)n where n is 0<n<3 iii) S(CH2)n where n is 0<n<3 iv) (CH2)n where n is 0≦n<4 v) C(O)(CH2)n where n is 0<n<3 vi) C(R4)=C(R5) vii) C≡C R4 and R5 each independently are hydrogen, C1-4alkyl, C2-6alkenyl, C2-6alkynyl, C3-7cycloalkyl, C1-4haloalkyl, C1-4 alkoxy, C1-4hydroxyalkyl, C1-4 alkylamino; X is CH or N; V is O; Q is selected from: i) an alkyl1 group, or ii) an aryl1 group, or iii) an heteroaryl1 group; an alkyl1 group is defined as a linear, branched or cycloalkyl group containing from 1 to 10 carbon atoms and optionally substituted with one or more hetereoatoms selected from halogen, oxygen, and nitrogen; trifluoromethyl, carboxyl, cyano, nitro, formyl; CO—R, COO—R, CONR—R′, SO2-R, and SO2NR—R′ wherein R and R′ are a linear or branched alkyl group containing 1 to 10 carbon atoms and optionally substituted with at least one heteroatom selected from a halogen, oxygen, and nitrogen; and a cycloalkyl group; an aryl1 group is defined as phenyl or a substituted variant thereof bearing any combination, at any one ring position, of one or more substituents selected from
halogen;an alkyl1 group;an aryl or heteroaryl group;trifluoromethyl, O-alkyl, carboxyl, cyano, nitro, formyl, hydroxy, NH-alkyl, N(alkyl)(alkyl), and amino group;NRCO—R′ or NRCOO—R′ or NRCONR′—R″ or NRSO2-R′ or NRSO2NR′—R″ or CO—R or COO—R or CONR—R′ or SO2-R or or SO2NRR′ wherein R, R′ and R″ each independently are selected from hydrogen, alkyl, aryl or heteroaryl group; an heteroaryl1 group is defined as a pyridyl, pyrimidinyl, pyrazinyl, pyridazinyl, thienyl, thiazolyl, imidazolyl, pyrazolyl, pyrrolyl, furanyl, oxazolyl, isoxazolyl, triazolyl, tetrazolyl, indolyl, benzimidazole, benzoxazole, benzothiazole, quinolinyl group, which may additionally bear any combination, at any one ring position, of one or more substituents selected from
halogen;an alkyl1 group;an aryl or heteroaryl group,trifluoromethyl, O-alkyl, carboxyl, cyano, nitro, formyl, hydroxy, NH-alkyl, N(alkyl)(alkyl), and amino group;NRCO—R′ or NRCOO—R′ or NRCONR′—R″ or NRSO2-R′ or NRSO2NR′—R″ or CO—R or COO—R or CONR—R′ or SO2-R or SO2NRR′ wherein R, R′ and R″ each independently are selected from hydrogen, alkyl, aryl or heteroaryl group; R1, R2 and R3 each independently are selected from hydrogen, halogen, a linear or branched alkyl group containing from 1 to 10 carbon atoms and optionally substituted with one or more hetereoatoms selected from halogen, oxygen, and nitrogen; trifluoromethyl, C1-6alkyloxy, amino, C1-6alkylamino, di(C1-6alkyl)amino, carboxyl, cyano, nitro, formyl, hydroxy, and CO—R, COO—R, CONR—R′, SO2-R, and SO2NR—R′ wherein R and R′ corresponds to hydrogen, alkyl, aryl or heteroaryl group; W is aryl1 or heteroaryl1. |
