MERCAPTOPURINE RIBONUCLEOSIDE ANALOGUES FOR ALTERING TELOMERASE MEDIATED TELOMERE
摘要
The present disclosure is directed toward pharmaceutical compositions and methods of using 6-mercaptopurine ribosides and analogues thereof for the treatement of cancer and other hyperproliferative diseases. The described compounds can be convereted into telomere substrates in vivo and can be recognized by telomerase for incorporation into telomeres of telomerase active cells, leading to induction of cell death of the telomerase active cells.
申请公布号
WO2014168947(A3)
申请公布日期
2015.02.19
申请号
WO2014US33330
申请日期
2014.04.08
申请人
THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM