| 发明名称 |
Methods of Treating Neurological Diseases |
| 摘要 |
The present invention is directed to novel treatment of controlling hippocampal neural circuit hyperexcitability occurring in a neurological disease or disorder associated with epileptogenesis in a subject in need of such treatment, comprising the step of contacting the hippocampus in said subject with a compound effective to restore excitatory/inhibitor balance thereby controlling the neural circuit hyperexcitability. Further provided is a method of treating a neurological disease or disorder associated with epileptogenesis in a subject in need of such treatment, comprising the step of administering an amount of an adenosine A1 receptor agonist pharmacologically effective to block epileptogenetic activities without blocking excitatory synaptic transmission. |
| 申请公布号 |
US2015051166(A1) |
申请公布日期 |
2015.02.19 |
| 申请号 |
US201313969252 |
申请日期 |
2013.08.16 |
| 申请人 |
Ziburkus Jokubas;Eriksen Jason;Gu Feng |
发明人 |
Ziburkus Jokubas;Eriksen Jason;Gu Feng |
| 分类号 |
A61K31/7076;A61K45/06 |
主分类号 |
A61K31/7076 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method of controlling hippocampal neural circuit hyperexcitability occurring in a neurological disease or disorder associated with epileptogenesis in a subject in need of such treatment, comprising the step of:
contacting the hippocampus in said subject with a compound effective to restore excitatory/inhibitor balance thereby controlling the neural circuit hyperexcitability. |
| 地址 |
Houston TX US |
