摘要 |
<p>The present invention provides chimeric proteins comprising a Factor VIII (FVIII) polypeptide and XTEN polypeptides. The FVIII polypeptide can have a reduced affinity for von Willebrand Factor (VWF). XTEN polypeptides of appropriate sizes are inserted into the FVIII polypeptide at particular locations in order to extend the half-life of the FVIII polypeptide. The invention also includes nucleotides, vectors, host cells, and methods of using the chimeric proteins, e.g., to treat bleeding diseases and disorders.</p> |
申请人 |
BIOGEN IDEC MA INC.;AMUNIX OPERATING INC. |
发明人 |
LIU, TONGYAO;CHANG, PEI-YUN;KULMAN, JOHN;SCHELLENBERGER, VOLKER;JIANG, HAIYAN;PETERS, ROBERT, T.;CHHABRA, EKTA, SETH |