| 主权项 |
1. A composition comprising a compound of Formula (IIa):or a pharmaceutically acceptable salt thereof, and one or more other therapeutic agents, wherein
each of Ra and Rb, independently, is H or C1-C6 alkyl optionally substituted with one or more -Q3-T3, in which Q3 is a bond or unsubstituted or substituted C1-C3 alkyl linker, and T3 is H, halo, 4 to 7-membered heterocycloalkyl, C1-C3 alkyl, ORd, COORd, —S(O)2Rd, or —NRdRe, in which each of Rd and Re is independently H or C1-C6 alkyl, or -Q3T3 is oxo; R7 is isopropyl or C1-C6 alkyl, C3-C8 cycloalkyl, piperidinyl, tetrahydropyran, tetrahydro-2H-thiopyranyl, cyclopentyl, or cyclohexyl, or 4 to 12-membered heterocycloalkyl, each optionally substituted with one or more -Q5-T5, in which Q5 is a bond, C(O), C(O)NRk, NRkC(O), S(O)2, or C1-C3 alkyl linker, Rk being H or C1-C6 alkyl, and T5 is H, halo, C1-C6 alkyl, hydroxyl, cyano, C1-C6 alkoxyl, amino, mono-C1-C6 alkylamino, di-C1-C6 alkylamino, C3-C8 cycloalkyl, C6-C10 aryl, 4 to 12-membered heterocycloalkyl, 5- or 6-membered heteroaryl, or S(O)qRq in which q is 0, 1, or 2 and Rq is C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C8 cycloalkyl, C6-C10 aryl, 4 to 12-membered heterocycloalkyl, or 5- or 6-membered heteroaryl, and T5 is optionally substituted with one or more substituents selected from the group consisting of halo, C1-C6 alkyl, hydroxyl, cyano, C1-C6 alkoxyl, amino, mono-C1-C6 alkylamino, di-C1-C6 alkylamino, C3-C8 cycloalkyl, C6-C10 aryl, 4 to 12-membered heterocycloalkyl, and 5- or 6-membered heteroaryl except when T5 is H, halo, hydroxyl, or cyano; or -Q5-T5 is oxo; and R8 is H, methyl, or ethyl. |
