Methods of identifying potential components for targeted drug delivery compositions

摘要

Methods of preparing compositions for preferential distribution of active agents to injury sites are provided. The compositions may comprise a polymer with hydrophilic properties and one or more active agents, such as compounds comprising hydrophilic metal ions. Because the delivery ligand and the active agent are specifically selected so the interactions between them are mainly of an ionic nature. Methods of identifying suitable components for such compositions are also disclosed.

主权项

1. A method of preparing compositions for distribution of active agents, the method comprises:
preparing a solution comprising a delivery ligand and one or more active agents, wherein the delivery ligand comprises polyethylene glycol (PEG), and the solution comprises the delivery ligand in an amount of between about 30% and about 40% w/v, and the one or more active agents comprises a magnesium compound in an amount of 0.8% w/v; subjecting the solution to one or more conditions to induce separation of phases in the solution; and isolating a phase comprising delivery ligand-active agent complexes.