Method of treating scars and β-catenin-mediated disorders using Nefopam compounds

摘要

Methods of treating disorders mediated by β-catenin comprising administration of Nefopam compounds are provided In particular, the treatment of disorders arising from excessive or undesired expression of β-catenin is contemplated Said compounds include Nefopam, analogues thereof, prodaigs thereof, and salts and solvates of Nefopam The β-catenin mediated disorders are preferably selected from the group consisting of fibroproliferative disorders (such as scars, aggressive fibramtoses, and fibroses) and cancer (such as colon cancer, melanoma, liver cancer, ovarian cancer, endometrial cancer, medullobalstoma pilomatricomas, and prostate cancer)

主权项

1. A method of treating a dermal scar in a mammal comprising administering a Nefopam compound selected from Nefopam, or a functionally equivalent, salt or solvate thereof, to the mammal, wherein the dermal scar is not a keloid.