Therapeutic agent or prophylactic agent for fibromyalgia

摘要

A therapeutic agent or prophylactic agent has an analgesic effect on both nociceptive pain and neuropathic pain and is effective in treatment of fibromyalgia. The agent includes as an effective ingredient a cyclohexane derivative or a pharmaceutically acceptable salt thereof or a prodrug thereof.

主权项

1. A method of treating fibromyalgia comprising administering a therapeutically effective amount of a cyclohexane derivative represented by the Formula (I):wherein
A is a substituent represented by the Formula (IIa) or (IIb): R1 and R2 are each independently a hydrogen atom, a chlorine atom, a C1-C3 haloalkyl group, a C1-C4 alkyl group or a C1-C4 alkoxy group; R3 is a hydrogen atom or a chlorine atom; R4 is a fluorine atom, a hydroxymethyl group or a hydroxyl group; R5 and R6 are each independently a hydrogen atom, a fluorine atom, a C1-C3 haloalkyl group, a carboxyl group, a methoxycarbonyl group, an ethoxycarbonyl group, a C1-C4 alkoxy group, a hydroxyl group or a C2-C5 alkylcarbonyloxy group, or optionally together form an oxo group; R7 and R8 are each independently a hydrogen atom or a fluorine atom; Y is an oxygen atom or a sulfur atom; Z is a nitrogen atom or a methine group or a pharmaceutically acceptable salt thereof or a prodrug thereof.