发明名称 |
免疫原特異的アジュバントとしての組換えタンパク粒 |
摘要 |
An immunogen-specific is adjuvant for a vaccine or inoculum is disclosed. The adjuvant is comprised of particulate recombinant protein body-like assemblies (RPBLAs) that contain a recombinant fusion protein that contains two portions peptide-linked together. A first portion is a protein body-inducing sequence (PBIS) and a second portion is a T-cell stimulating immunogenic polypeptide whose sequence is that of a pathogenic polypeptide sequence present in or induced by a vaccine or inoculum. The adjuvant, when used as an inoculum in a host animal without a prior priming vaccination or inoculation, does not induce production of antibodies or T cell activation to the pathogenic sequence. |
申请公布号 |
JP5667062(B2) |
申请公布日期 |
2015.02.12 |
申请号 |
JP20110530504 |
申请日期 |
2009.10.09 |
申请人 |
エラ、ビオテック、ソシエダッド、アノニマERA BIOTECH, S.A. |
发明人 |
エドワール、ピーター、リビッキー;アン、エリザベス、マイヤーズ;フランソワ、デベサ;パブロ、マルサバル、ルナ;インガ、イザベル、ヒッツェロート;ペーター、エールシュレーガー |
分类号 |
A61K48/00;A61P37/04;A61P43/00 |
主分类号 |
A61K48/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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