摘要 |
<p>Crystallisation is brought about in a process utilising supercritical fluid either as solvent or antisolvent, wherein a solution that is being changed into a supersaturated condition is subjected to intense ultrasound to initiate nucleation. The solution may have the supercritical fluid as solvent, being changed to being supersaturated by a first-stage expansion. Or a solution may be contacted with the supercritical fluid as an antisolvent, so it becomes supersaturated.</p> |