发明名称 |
LOW DENSITY LIPOPROTEIN-RELATED PROTEIN 6 (LRP6) - HALF LIFE EXTENDER CONSTRUCTS. |
摘要 |
<p>The present invention relates to LRP6 constructs that bind to LRP6 receptor. The LRP6 constructs comprise at least one LRP6 binding moiety and a half-life extender molecule such that the LRP6 construct inhibit the Wnt signaling pathway without potentiation of the Wnt signal. The LRP6 constructs also have an increased half-life to provide more time for the therapeutic benefit.</p> |
申请公布号 |
MX2014005411(A) |
申请公布日期 |
2015.02.12 |
申请号 |
MX20140005411 |
申请日期 |
2012.11.02 |
申请人 |
NOVARTIS AG |
发明人 |
ANDREAS LOEW;DAVID JENKINS;MING LEI;LI ZHOU |
分类号 |
C07K16/28 |
主分类号 |
C07K16/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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