Method for Transdermal Iontophoretic Delivery of Chelated Agents

摘要

Embodiments provide devices, systems and methods for the transdermal delivery of chelated compounds. One embodiment provides a method for the iontophoretic transdermal delivery of a chelated iron complex for the treatment of anemia. A first patch comprising an active electrode and a chelated iron complex is applied to the skin; a second patch containing an electrode is also applied. An electrical current is then delivered to the skin from the active electrode. The chelated complex is transported across the skin via electromotive force from the current, with the iron being substantially chromogenically unreactive with the skin during transport so that there is little or no tattooing of the skin due to the formation of insoluble oxidative products. The complex is then dissociated by phagocytosis or related process to release the iron where it may be bound by transferrin or ferritin and carried to other sites for storage or metabolic use.

主权项

1. A method for the iontophoretic transdermal delivery of a chelated iron complex, the method comprising:
applying an iontophoretic transdermal delivery device to the skin of a subject, the device comprising an electrode and iron comprising a chelated iron complex comprising ferric pyrophosphate; delivering an electrical current to the skin using the electrode; and thus transporting the chelated iron complex across the skin, wherein the complex is transported across the skin without precipitation of iron in the skin, thereby reducing chromogenic reactions with the skin relative to the transport of non-chelated iron.