| 发明名称 |
CAPECITABINE RAPIDLY DISINTEGRATING TABLETS |
| 摘要 |
There is provided a film coated pharmaceutical composition comprising 5′-deoxy-5-fluoro-N-[(pentyloxy)-carbonyl]-cytidine (capecitabine) and at least one disintegrant selected from the group comprising of crospovidone (particle size <15-400μ), croscarmellose sodium, sodium starch glycolate, low-substituted hydroxypropylcellulose, Pharmaburst C or any combination of these, together with other pharmaceutically acceptable excipients to form a rapidly disintegrating tablet. This tablet disintegrates in water at 37° C. in a USP Disintegration Apparatus in less than 2 minutes, preferably 1 minute and have a hardness of 8-13 strong Cobb-Units. |
| 申请公布号 |
US2015044287(A1) |
申请公布日期 |
2015.02.12 |
| 申请号 |
US201414521357 |
申请日期 |
2014.10.22 |
| 申请人 |
Hoffmann-La Roche Inc. |
发明人 |
Bachynsky Maria Oksana;Infeld Martin Howard;Rashed Mohammad;Shah Navnit Hargovindas |
| 分类号 |
A61K9/20;A61K31/7068;A61K9/28 |
主分类号 |
A61K9/20 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A film coated pharmaceutical composition comprising capecitabine and at least one disintegrant, said composition disintegrating in water at 37° C. in a USP Disintegration Apparatus in less than 2 minutes and having a hardness of 8-13 strong Cobb-Units. |
| 地址 |
Little Falls NJ US |
