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1. A compound of formula (II): in which:
R1 represents a halogen atom and R2 represents an —OH, an acyl group derived from an amino acid AA, or a (C1-C4)alkanoyloxy group or alternatively R1 and R2 form an epoxide unit;
AA denotes a natural or unnatural amino acid;R3 represents a (C1-C6)alkyl group;R4 and R5 both represent H or together form a double bond CH═CH between C13 and C14;R6 and R7 represent, independently of each other, H or a (C1-C6)alkyl group;R8 and R9 represent, independently of each other, H or a (C1-C6)alkyl group;R10 represents at least one substituent of the phenyl nucleus chosen from: H, an OH, (C1-C4)alkoxy, a halogen atom, —NH2, —NH(C1-C6)alkyl or —N(C1-C6)alkyl2;R11 represents at least one substituent of the phenyl nucleus chosen from H and a (C1-C4)alkyl group;L represents a linker in the ortho (O), meta (m) or para (p) position of the phenyl nucleus bearing the unit RCG1 chosen from: -G′ X (CR13R14)t(OCH2CH2)y(CR15R16)u Q RCG1; -G′ X (CR13R14)t(OCH2CH2)y—Y′—(CR15R16)u Q RCG1; -G′ X (CR13R14)t(CR17═CR18)(CR15R16)u(OCH2CH2)y Q RCG1; -G′ X (CR13R14)t(OCH2CH2)y(CR17═CR18)(CR15R16)u Q RCG1; -G′ X (CR13R14)t-phenyl-(CR15R16)u Y′ Q RCG1; -G′ X (CR13R14)t-furyl-(CR15R16)u Y′ Q RCG1; -G′ X (CR13R14)t-oxazolyl-(CR15R16)u Y′ Q RCG1; -G′ X (CR13R14)t-thiazolyl-(CR15R16)u Y′ Q RCG1; -G′ X (CR13R14)t-thienyl-(CR15R16)u Y′ Q RCG1; -G′ X (CR13R14)t-imidazolyl-(CR15R16)u Y′ Q RCG1; -G′ X (CR13R14)t-piperazinyl-CO(CR15R16)u Y′ Q RCG1; -G′ X (CR13R14)t-piperidyl-methyl-NR12—CO(CR15R16), Y′ Q RCG1; -G′ X (CR13R14)t-piperidyl-(CR15R16)u Q RCG1; -G′ X (CR13R14)t-piperidyl-NR12—(CR15R16)u Y′ Q RCG1; -G′ X (CR13R14)t-triazolyl-(CR15R16)u Y′ Q RCG1; -G′ X (CR13R14)t-triazolyl-(CR15R16)u Y′ Q RCG1; -G′ X (CR13R14)t-phenyl-(CR15R16)u Q RCG1; -G′ X (CR13R14)t-furyl-(CR15R16)u Q RCG1; -G′ X (CR13R14)t-oxazolyl-(CR15R16)u Q RCG1; -G′ X (CR13R14)t-thiazolyl-(CR15R16)u Q RCG1; -G′ X (CR13R14)t-thienyl-(CR15R16)u Q RCG1; -G′ X (CR13R14)t-imidazolyl-(CR15R16)u Q RCG1; -G′ X (CR13R14)t-piperazinyl-(CR15R16)u Q RCG1; -G′ X (CR13R14)t-piperidyl-(CR15R16)u Q RCG1; -G′ X (CR13R14)t-piperidyl-methyl-NR12—(CR15R16)u Q RCG1; -G′ X (CR13R14)t-piperidyl-NR12—(CR15R16)u Q RCG1; -G′ X (CR13R14)t-triazolyl-(CR15R16)u Q RCG1; -G″ Y (CR13R14)t(OCH2CH2)y(CR15R16)u Q RCG1; -G″ Y (CR13R14)t(OCH2CH2)y—Y′—(CR15R16)u Q RCG1; -G″ Y (CR13R14)t(CR17═CR18)(CR15R16)u(OCH2CH2)y Q RCG1; -G″ Y (CR13R14)t(OCH2CH2)y(CR17═CR18)(CR15R16)u Q RCG1; -G″ Y (CR13R14)t-phenyl-(CR15R16)u Y′ Q RCG1; -G″ Y (CR13R14)t-furyl-(CR15R16)u Y′ Q RCG1; -G″ Y (CR13R14)t-oxazolyl-(CR15R16)u Y′ Q RCG1; -G″ Y (CR13R14)t-thiazolyl-(CR15R16)u Y′ Q RCG1; -G″ Y (CR13R14)t-thienyl-(CR15R16)u Y′ Q RCG1; -G″ Y (CR13R14)t-imidazolyl-(CR15R16)u Y′ Q RCG1; -G″ Y (CR13R14)t-piperazinyl-CO(CR15R16)u Y′ Q RCG1; -G″ Y (CR13R14)t-piperidyl-methyl-NR12—CO(CR15R16)u Y′ Q RCG1; -G″ Y (CR13R14)t-piperidyl-(CR15R16)u Q RCG1; -G″ Y (CR13R14)t-piperidyl-NR12—(CR15R16)u Y′ Q RCG1; -G″ Y (CR13R14)t-triazolyl-(CR15R16)u Y′ Q RCG1; -G″ Y (CR13R14)t-phenyl-(CR15R16)u Q RCG1; -G″ Y (CR13R14)t-furyl-(CR15R16)u Q RCG1; -G″ Y (CR13R14)t-oxazolyl-(CR15R16)u Q RCG1; -G″ Y (CR13R14)t-thiazolyl-(CR15R16)u Q RCG1; -G″ Y (CR13R14)t-thienyl-(CR15R16)u Q RCG1; -G″ Y (CR13R14)t-imidazolyl-(CR15R16)u Q RCG1; -G″ Y (CR13R14)t-piperazinyl-(CR15R16)u Q RCG1; -G″ Y (CR13R14)t-piperazinyl-(CR15R16)u Q CCR1; G″ Y (CR13R14)t-piperidyl-(CR15R16)u Q RCG1; -G″ Y (CR13R14)t-piperidyl-methyl-NR12—(CR15R16)u Q RCG1; -G″ Y (CR13R14)t-piperidyl-NR12—(CR15R16)u Q RCG1; or -G″ Y (CR13R14)t-triazolyl-(CR15R16)u Q RCG1; in which formulae:
G′ represents a —CH═CH— or —(CH2)n— group;G″ represents a —(CH2)n— group;n represents an integer ranging from 1 to 6;X represents a single bond or a —CO—, —COO— or —CONR12—, wherein the CO is attached to G′;Y represents a —O—, —OCO—, —OCOO—, —OCONR12—, —NR12—, —NR12CO—, —NR12CONR′12—, —NR12COO— or —S(O)q—, wherein the O and the NR12 are attached to G″;q represents an integer that may be 0, 1 or 2;Y′ represents a —O—, —OCO—, —OCOO—, —OCONR12—, —NR12—, —NR12CO—, —NR12CONR′12—, —NR12COO—, —S(O)q—, —CO—, —OCO—, or —CONR12—;R12, R′12, R13, R14, R15, R16, R17 and R18 represent, independently of each other, H or a (C1-C6)alkyl group;t, u and y represent integers that may range from 0 to 20 and such that t+u+y is greater than or equal to 1; in the case of the linker of formula -G″Y(CR13R14)t(OCH2CH2)y—Y′—(CR15R16)u Q RCG1, if y is 0 and Q represents a single bond, then u cannot be 0;
Q represents a single bond, a (C1-C10)alkylene group or a (OCH2CH2)l group, wherein i is an integer ranging from 1 to 20; RCG1 represents —SZa, —C(═O)—ZbRb,with R12 representing H or (C1-C6)alkyl;
or L is chosen from: in which formulae: represents one of the following 9 groups: n represents an integer ranging from 1 to 6;ALK represents a group (C1-C12)alkylene;R12 and R′12 represent, independently of each other, H or a group (C1-C6)alkyl;i represents an integer ranging from 1 to 20; or alternatively L is a linker of formula (IV): in which:
(AA)w represents a sequence of w amino acids AA connected together via peptide bonds;w represents an integer ranging from 1 to 12;n represents an integer ranging from 1 to 6;D represents one of the following units: for which:
R12 represents H or a (C1-C6)alkyl group;R19, R20, R21 and R22 represent, independently of each other, H, a halogen atom, —OH, CN or a (C1-C4)alkyl group;T attached to (CH2), represents NR12 or O;V1 represents O, S or NR12;V2 represents CR22 or N;V3, V4 and V5 are chosen, independently of each other, from CR22 and N;Za represents H or the group —SRa, wherein Ra represents a (C1-C6)alkyl, (C3-C7)cycloalkyl, aryl, heteroaryl or (C3-C7)heterocycloalkyl;Zb represents a single bond, —O— or —NH—, wherein Rb represents H, (C1-C6)alkyl, (C3-C7)cycloalkyl, aryl, heteroaryl or (C3-C7)heterocycloalkyl. |
