发明名称 |
Pharmaceutical/cosmetic, E.G., anti-acne compositions comprising at least one naphthoic acid compound, benzoyl peroxide and at least one film-forming agent |
摘要 |
Stable pharmaceutical/cosmetic compositions for topical application, notably for the treatment of acne vulgaris include, formulated into a physiologically acceptable medium, at least one naphthoic acid compound, benzoyl peroxide and at least one film-forming agent, the at least one naphthoic acid compound and the benzoyl peroxide advantageously being in a dispersed form therein. |
申请公布号 |
US8952066(B2) |
申请公布日期 |
2015.02.10 |
申请号 |
US201012788865 |
申请日期 |
2010.05.27 |
申请人 |
Galderma Research & Development |
发明人 |
Mallard Claire |
分类号 |
A61K8/04;A61K8/38;A61K47/18;A61K47/10;A61Q19/00;A61K31/327;A61K31/192;A61K8/368;A61K8/81;A61K47/44;A61Q5/00;A61K47/36;A61K47/32;A61K8/73;A61K47/38;A61K9/00;A61K9/06;A61K47/24;A61Q19/08;A61K47/14 |
主分类号 |
A61K8/04 |
代理机构 |
Dentons US LLP |
代理人 |
Dentons US LLP |
主权项 |
1. A stable, topically applicable pharmaceutical/cosmetic composition non-irritant over the long term, comprising otherwise essentially incompatible amounts of at least one naphthoic acid compound and benzoyl peroxide, said naphthoic acid compound and said benzoyl peroxide being in dispersed form in said composition; and, providing degradation-resistance thereto, a thus effective amount of at least one film-forming agent, formulated into a topically applicable, physiologically acceptable medium therefor as a gel, lotion, cream or emulsifier-free cream, wherein the at least one film-forming agent is at least one filmy forming polymer selected from the group consisting of polyvinylpyrrolidones, polysaccharides other than cellulose and derivatives thereof, acrylic copolymers and polyvinyl alcohols, said composition excluding ethyl alcohol, said pharmaceutical/cosmetic composition comprising,
from 0.1% to 0.3% of 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphthoic acid as the naphthoic acid; from 1% to 10% of benzoyl peroxide; from 30% to 95% of water; from 0.5% to 10% of the at least one film-forming polymer; from 0.10% to 3% of one or more gelling agents and/or suspending agents and/or pH-independent gelling agents; from 0% to 1.5% of one or more chelating agents; from 0.1% to 10% of one or more wetting agents; and from 0.01% to 3% of preservatives. |
地址 |
Biot FR |