Translocation and nucleotide reading mechanisms for sequencing nanodevices

摘要

By driving molecules electrophoretically through a nanopore, single molecule detection can be achieved. To enhance translocational control, functionalized and non-functionalized electrodes are strategically placed around or above a nanopore. Changes in transmission spectra and input voltage detected by electrodes allow accurate identification of single molecules as they pass through a nanopore.

主权项

1. A molecule capturing device comprising a solid state membrane containing nanopores, each nanopore defining a space within which molecules can pass and be detected, each nanopore comprising electrodes, the electrodes being functionalized with a material capable to capture a molecule passing through the nanopore by way of hydrogen bonding between the material and the molecule, wherein the electrodes are four or eight electrodes.