Microbiologically sound and stable solutions of gamma-hydroxybutyrate salt for the treatment of narcolepsy

摘要

Disclosed are formulations of gamma-hydroxybutyrate in an aqueous medium that are resistant to microbial growth. Also disclosed are formulations of gamma-hydroxybutyrate that are also resistant to the conversion into GBL. Disclosed are methods to treat sleep disorders, including narcolepsy, with these stable formulations of GHB. The present invention also provides methods to treat alcohol and opiate withdrawal, reduced levels of growth hormone, increased intracranial pressure, and physical pain in a patient.

主权项

1. A method of treating a condition responsive to gamma-hydroxybutyrate comprising orally administering two doses to a patient afflicted with the condition:
(i) an aqueous composition comprising a first dose of about 3 to about 10 grams of salt of gamma-hydroxybutyrate; and (ii) an aqueous composition comprising a second dose of about 3 to about 10 grams of a salt of gamma-hydroxybutyrate within 2.0 to 5 hours after the first dose; wherein two doses are administered to the patient for a total amount of between 6 to 20 grams per day wherein the aqueous composition of the first dose and the aqueous composition of the second dose each were prepared by diluting a solution of gamma-hydroxybutyrate of 350 to 750 mg/ml.