| 发明名称 | Modulators of ATP-binding cassette transporters | ||
| 摘要 | Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention. | ||
| 申请公布号 | US8952049(B2) | 申请公布日期 | 2015.02.10 |
| 申请号 | US201313781392 | 申请日期 | 2013.02.28 |
| 申请人 | Vertex Pharmaceuticals Incorporated | 发明人 | Ruah Sara Sabina Hadida;Grootenhuis Peter Diederik Jan;Van Goor Fredrick F.;Zhou Jinglan;Bear Brian Richard;Miller Mark Thomas;McCartney Jason;Numa Mehdi Michel Djamel |
| 分类号 | A61K31/36;C07D405/12;C07D209/08;C07D471/04;C07D233/64;C07D403/12 | 主分类号 | A61K31/36 |
| 代理机构 | Honigman Miller Schwartz and Cohn LLP | 代理人 | Honigman Miller Schwartz and Cohn LLP ;Berven Heidi M.;O'Brien Jonathan P. |
| 主权项 | 1. A method of treating male infertility or pancreatic insufficiency in a patient, comprising the step of administering to said patient a compound which is: or a pharmaceutically acceptable salt thereof. | ||
| 地址 | Boston MA US | ||