| 发明名称 | Methods and compositions for the treatment of eye disorders with increased intraocular pressure | ||
| 摘要 | The present invention relates to methods and compositions that decrease intraocular pressure (IOP) of the eye. The compositions of the invention comprise short interfering nucleic acid molecules (siNA) including, but not limited to, siRNA that decrease expression of genes associated with production or drainage of intraocular fluid. The compositions of the invention can be used in the preparation of a medicament for the treatment of eye conditions displaying increased IOP such as glaucoma, infection, inflammation, uveitis, and diabetic retinopathy. The methods of the invention comprise the administration to a patient in need thereof of an effective amount of one or more siNAs of the invention. | ||
| 申请公布号 | US8951982(B2) | 申请公布日期 | 2015.02.10 |
| 申请号 | US201313744881 | 申请日期 | 2013.01.18 |
| 申请人 | Sylentis S.A.U. | 发明人 | Jiménez Ana I.;Sesto Ángela;Gascón Irene;Román José P.;González de Buitrago Gonzalo |
| 分类号 | C12N15/11;C12N15/113 | 主分类号 | C12N15/11 |
| 代理机构 | King & Spalding LLP | 代理人 | Brivanlou Margaret B.;Serunian Leslie A.;King & Spalding LLP |
| 主权项 | 1. An isolated nucleic acid molecule consisting essentially of a double stranded, short interfering ribonucleic acid (siRNA) of 19 nucleotides in length, wherein the nucleotide sequence of one strand of the siRNA is the sequence as set forth in SEQ ID NO:139 or SEQ ID NO: 1841, which isolated siRNA specifically targets adrenergic beta receptor 2. | ||
| 地址 | Madrid ES | ||