发明名称 |
USE OF AN ANTIBODY AGAINST S100A8 OR S100A9 AS CHEMOTACTIC FACTOR INHIBITOR FOR MODULATING INFLAMMATORY REACTIONS |
摘要 |
<p>The present invention relates to compounds and methods for modulating, reducing or inhibiting, inflammatory reactions in a patient. Particularly, inflammatory reactions that are targeted by the present invention are cell migration, secretion of toxic products and proteolysis at a site of inflammation. Reduction of inflammation manifestations and reactions occurs by using an anti-S100 polynucleotide or polypeptide inhibitor or antagonist, which is essentially targeted against S100A8, S100A9 or S100A12, alone or in combination with other inhibitors of chemokines or immune modulating products.</p> |
申请公布号 |
CA2489860(C) |
申请公布日期 |
2015.02.10 |
申请号 |
CA20032489860 |
申请日期 |
2003.06.20 |
申请人 |
UNIVERSITE LAVAL |
发明人 |
TESSIER, PHILIPPE A.;RYCKMAN, CARLE;VANDAL, KAREN;ROULEAU, PASCAL |
分类号 |
A61K48/00;A61K31/7105;A61K38/17;A61K38/19;A61K39/395;A61P11/06;A61P17/06;A61P19/02;A61P29/00;A61P35/02;A61P43/00;C07K16/24 |
主分类号 |
A61K48/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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