发明名称 Bioactive water fraction from <i>Gomphostema niveum</i>
摘要 The present invention relates to a novel bioactive water fraction obtained from the leaves of an herb named Gomphostema niveum commonly found in North Eastern part of India, and which is useful for inhibiting the growth of malarial parasite Plasmodium falciparum. The present invention also relates to a method for the extraction of said bioactive fraction. The present invention also provides methods for treatment of malaria using such bioactive water fractions and use of such bioactive water fractions for the treatment of malaria.
申请公布号 US8951581(B2) 申请公布日期 2015.02.10
申请号 US201213400921 申请日期 2012.02.21
申请人 The Director General, Defence Research and Development Organisation 发明人 Kaushik Mahabir Prashad;Thavaselvam Duraipandian;Nivsarkar Manisha;Kumar Sanjay;Sekhar Krishnamurthy;Gogoi Hemant Kumar;Koch Deba
分类号 A01N65/00;A61K36/53 主分类号 A01N65/00
代理机构 Ladas &amp; Parry LLP 代理人 Ladas &amp; Parry LLP
主权项 1. A method for making an aqueous hexane, aqueous diethyl ether, aqueous chloroform or aqueous ethanol extract of Gomphostema niveum leaf comprising air drying leaves of Gomphostema niveum to produce air dried leaves of Gomphostema niveum, powdering the air dried leaves of Gomphostema niveum to produce powder of leaves of Gomphostema niveum and subjecting the powder of leaves of Gomphostema niveum to extraction with water at reflux temperature, filtering the extract of leaves of Gomphostema niveum to produce a water extract of Gomphostema niveum, further extracting the water extract of Gomphostema niveum by liquid-liquid extraction using solvents selected from the group consisting of hexane, diethyl ether, chloroform and ethanol on the basis of increasing polarity to produce an aqueous hexane, aqueous diethyl ether, aqueous chloroform or aqueous ethanol extract, then the aqueous hexane. aqueous diethyl ether, aqueous chloroform or aqueous ethanol extract is concentrated to dryness under reduced pressure of about 150 psi and at a temperature of about 30° C. to produce the aqueous hexanes aqueous diethyl ether, aqueous chloroform or aqueous ethanol extract of Gomphostema niveum leaf.
地址 New Delhi IN