ELECTRONIC EXPRESSION OF THE INWARD RECTIFIER IN CARDIOCYTES DERIVED FROM HUMAN INDUCED PLURIPOTENT STEM CELLS

摘要

Systems and methods are provided for improving action potential morphology in iPSC- derived cardiac myocytes and utilizing such myocytes. Improved morphology may include, for example, physiological resting membrane potentials. Membrane voltages of the myocyte are measured and a synthetic inward rectifying current is applied to the myocyte based on the membrane voltage.