发明名称 |
ANTIBODIES OR FUSION PROTEINS MULTIMERIZED VIA HOMOMULTIMERIZING PEPTIDE |
摘要 |
The invention provides antibodies or fusion proteins with modified heavy chain IgG constant regions that promote assembly of multimeric complexes. Within an antibody or fusion protein unit there are two heavy chains each including at least CH2 and CH3 regions. The two heavy chains bear complementary modifications (e.g., knob and hole) to promote coupling of the heavy chains within a unit. One and only one of the heavy chains in a unit is fused at its C-terminus to a homomultimerizing peptide. The presence of the homomultimerizing peptide promotes association between units. For example, if the homomultimerizing peptide is a homotrimerizing peptide it promotes association of three units to form a trimeric complex. |
申请公布号 |
US2015038682(A1) |
申请公布日期 |
2015.02.05 |
申请号 |
US201414449076 |
申请日期 |
2014.07.31 |
申请人 |
JN BIOSCIENCES LLC |
发明人 |
Tsurushita Naoya;Tso J. Yun |
分类号 |
C07K16/28 |
主分类号 |
C07K16/28 |
代理机构 |
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代理人 |
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主权项 |
1. An antibody or fusion protein comprising first and second heavy chain constant regions associated with one another as a heterodimer, each chain comprising IgG CH2 and CH3 regions, and one of the chains comprising a homomultimerizing peptide linked to the C-terminus of the CH3 region. |
地址 |
Mountain View CA US |