发明名称 |
NOVEL DERIVATIVES OF A 3,4-DIHYDROISOQUINOLINE-3-CARBOXYLIC ACID HAVING ANTI-CANCER PROPERTIES, A METHOD FOR THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITIONS COMPRISING SAID DERIVATIVES, AND THEIR USE |
摘要 |
The object of the invention is 3,4-dihydroisoquinoline derivative of structure represented by formula I, wherein R1is selected from the group consisting of H, COOEt, COOH, COOBn; R2 is selected from the group consisting of H, COOEt, COOH, COOBn; R3is selected from the group consisting of OH, OBn; R4is selected from the group consisting of OH, H, OBn; Rsis selected from the group consisting of OH, OBn; and isomers, salts, hydrates and solvates thereof, as well as the method of preparation thereof; pharmaceutical composition comprising the above mentioned derivative and use thereof. |
申请公布号 |
WO2015015420(A1) |
申请公布日期 |
2015.02.05 |
申请号 |
WO2014IB63518 |
申请日期 |
2014.07.29 |
申请人 |
NARODOWY INSTYTUT ZDROWIA PUBLICZNEGO PA&Nacute,STWOWY ZAK&Lstrok,AD HIGIENY;UNIWERSYTET PRZYRODNICZO-HUMANISTYCZNY W SIEDLCACH |
发明人 |
SOLECKA, JOLANTA;KAW&Eogon,CKI, ROBERT;POSTEK, MAGDALENA;PYPOWSKI, KRZYSZTOF;ZIEMSKA, JOANNA;GU&Sacute,PIEL, ADAM |
分类号 |
C07D217/26;A61K31/47;A61P35/00 |
主分类号 |
C07D217/26 |
代理机构 |
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地址 |
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