Therapeutic agent or prophylactic agent for neuropathic pain

摘要

A therapeutic agent or a prophylactic agent for neuropathic pain provides a synergistically-enhanced analgesic effect at a dose at which a calcium channel α2δ ligand does not produce any side effects as well as which agent does not produce any new side effects on the central nervous system. The therapeutic agent or a prophylactic agent for neuropathic pain includes as effective ingredients a cyclohexane derivative, represented by the following formula, or a pharmaceutically acceptable salt thereof or a prodrug thereof, and a calcium channel α2δ ligand.;

主权项

1. A therapeutic agent for the treatment of neuropathic pain comprising as effective ingredients a cyclohexane derivative represented by Formula (I):wherein
A is a substituent represented by Formula (IIa): wherein R1 and R2 are each independently a C1-C4 alkyl group or a C1-C4 alkoxy group; R3 is a hydrogen atom; R4 is a hydroxyl group; R5 and R6 are each independently a hydrogen atom, or a hydroxyl group; R7 and R8 are a hydrogen atom; Z is a methine group or a pharmaceutically acceptable salt thereof and a calcium channel α2δ ligand which is pregabalin or gabapentin.