发明名称 |
NOVEL SAPONIN COMPOUNDS, METHODS OF PREPARATION THEREOF, USE THEREOF AND PHARMACEUTICAL COMPOSITIONS |
摘要 |
<p>This invention relates to novel saponin compounds of formula II wherein MBz denotes p-methoxybenzoyl, and R is selected from the group comprising C6-10 aryl, C6-10 aryl-C1-4 alkyl-, C1-18 alkanoyl, C3-18 alkenoyl, C6-10 aryl-C(O)-, C6-10 aryl-C1-4 alkyl-C(O)-, wherein each of the groups can optionally be substituted. These compounds possess a selective cytostatic activity, useful, e.g., in the treatment of proliferative diseases. The invention further relates to methods of preparation of the novel com-pounds and to a pharmaceutical composition containing these compounds.</p> |
申请公布号 |
CA2751263(C) |
申请公布日期 |
2015.02.03 |
申请号 |
CA20102751263 |
申请日期 |
2010.02.08 |
申请人 |
UNIWERSYTET W BIALYMSTOKU;UNIVERZITA PALACKEHO V OLOMOUCI;BIOAPEX, S.R.O. |
发明人 |
MORZYCKI, JACEK WITOLD;WOJTKIELEWICZ, AGNIESZKA;OKLESTKOVA, JANA;HOFFMANNOVA, LUCIE;STRNAD, MIROSLAV |
分类号 |
C07J17/00;A61K31/58;A61P35/00 |
主分类号 |
C07J17/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|