发明名称 |
Polynucleotides encoding Notch receptor antibodies |
摘要 |
The present invention relates to Notch-binding agents and Notch antagonists and methods of using the agents and/or antagonists for treating diseases such as cancer. The present invention provides antibodies that specifically bind to a non-ligand binding region of the extracellular domain of one or more human Notch receptor, such as Notch2 and/or Notch3, and inhibit tumor growth. The present invention further provides methods of treating cancer, the methods comprising administering a therapeutically effective amount of an antibody that specifically binds to a non-ligand binding region of the extracellular domain of a human Notch receptor protein and inhibits tumor growth. |
申请公布号 |
US8945873(B2) |
申请公布日期 |
2015.02.03 |
申请号 |
US201313782671 |
申请日期 |
2013.03.01 |
申请人 |
OncoMed Pharmaceuticals, Inc. |
发明人 |
Gurney Austin L.;Hoey Timothy Charles;Htun van der Horst Edward Thein;Sato Aaron Ken;Liu Yuan Ching;Bruhns Maureen Fitch;Lewicki John A. |
分类号 |
C07H21/04;C12N7/01;C12N5/12;C12N15/09;C12N15/63;C12N15/79;C12P21/08;C07K16/28;C07K16/30;A61K39/395;A61K45/06;C07K16/46;C07K16/22;C07K14/705;C07K14/71;C07K14/435;A61K39/00 |
主分类号 |
C07H21/04 |
代理机构 |
Sterne, Kessler, Goldstein & Fox P.L.L.C. |
代理人 |
Sterne, Kessler, Goldstein & Fox P.L.L.C. |
主权项 |
1. An isolated polynucleotide encoding an antibody that specifically binds human NOTCH2 and/or NOTCH3, wherein the antibody comprises:
(a) a heavy chain CDR1 comprising SSSGMS (SEQ ID NO:5), a heavy chain CDR2 comprising VIASSGSNTYYADSVKG (SEQ ID NO:6), and a heavy chain CDR3 comprising SIFYTT (SEQ ID NO:51) or GIFFAI (SEQ ID NO:7); and (b) a light chain CDR1 comprising RASQSVRSNYLA (SEQ ID NO:8), a light chain CDR2 comprising GASSRAT (SEQ ID NO:9), and a light chain CDR3 comprising QQYSNFPI (SEQ ID NO:10). |
地址 |
Redwood City CA US |