Use of calixarenes associated with an antibiotic in the treatment of bacterial infections

摘要

A product comprising a calixarene for its use in the treatment of pathologies involving at least one bacterial strain having a resistance to at least one defined antibiotic, on patients undergoing simultaneous or sequential treatment with a given antibiotic to which said bacterial strain optionally has a resistance.

主权项

1. A method of treating an infection by a bacterial strain having an acquired resistance to at least one defined antibiotic, comprising administering to a patient in need thereof an effective amount of a product, said patient undergoing simultaneous or sequential treatment by said antibiotic, the product comprising a calixarene represented by Formula I below: in which:
(i) n=an integer from 4 to 16,(ii) m=an integer from 1 to 10,(iii) X is chosen from:
a hydrogen,an alkyl group, the number of carbons being from 1 to 20,a halogen chosen from Cl, Br, I, oran amphiphilic group chosen from an anionic group or a cationic group.