Bone substitute compositions, methods of preparation and clinical applications

摘要

The present invention relates to bone substitute compositions and methods of their preparation, and their use in a wide variety of clinical applications. The compositions include calcium phosphate, acidic calcium salt, basic calcium salt, sodium hydrogen phosphate and porogen. The compositions further include a mixing liquid. The compositions can optionally include biological signaling molecules and/or a growth compound. Further, the compositions can optionally include a plasticizer.

主权项

1. A method of repairing or replacing defective native bone tissue, comprising:
preparing a bone substitute composition, comprising:
combining calcium phosphate, acidic calcium salt, basic calcium salt, material selected from the group consisting of monosodium hydrogen phosphate, disodium hydrogen phosphate and mixtures thereof, and porogen to form a powder component; andmixing the powder component with a liquid colloidal mixture comprising nanoparticulate calcium phosphate and calcium salt; obtaining a patient having defective native bone tissue; and administering in vivo the bone substitute composition in a form selected from the group consisting of paste, putty and cement, into the patient at the site of the defective native bone tissue.