| 发明名称 | Substituted porphyrins | ||
| 摘要 | The present invention relates, in general, to a method of modulating physiological and pathological processes and, in particular, to a method of modulating cellular levels of oxidants and thereby processes in which such oxidants are a participant. The invention also relates to compounds and compositions suitable for use in such methods. | ||
| 申请公布号 | US8946202(B2) | 申请公布日期 | 2015.02.03 |
| 申请号 | US201314019295 | 申请日期 | 2013.09.05 |
| 申请人 | Aeolus Sciences, Inc.;National Jewish Health;Duke University | 发明人 | Crapo James D.;Day Brian J.;Trova Michael P.;Gauuan Polvina Jolicia;Kitchen Douglas B.;Fridovich Irwin;Batinic-Haberle Ines |
| 分类号 | A01N55/02;A01N43/36;C07D487/22;C07B47/00 | 主分类号 | A01N55/02 |
| 代理机构 | Kilpatrick Townsend & Stockton LLP | 代理人 | Kilpatrick Townsend & Stockton LLP |
| 主权项 | 1. A method of treating cardiomyopathy mediated by oxidative stress in a patient in need thereof, said method comprising administering to said patient an effective amount of a compound of formulaor pharmaceutically accept salt thereof, wherein R1 and R3 are the same and are: R2 and R4 are the same and are: Y is halogen or —CO2X, each X is the same or different and is an alkyl; and each R5 is the same or different and is H or alkyl. | ||
| 地址 | Mission Viejo CA US | ||