| 摘要 |
本发明系关于一种用于制备4-( 10 B)二羟基硼基-L-苯丙胺酸化合物，该化合物具有式(I)所示之结构，其中R代表一保护基，且该保护基系选自于由第三丁氧羰基、三苯甲基、3,5-二甲氧苯异丙氧羰基、2-(4-联苯)异丙氧羰基及2-硝苯基亚磺醯基所组成之族群，该化合物的 10 硼纯度系大于或等于98%，且其镜像超越值系大于或等于99%。;Provided is a compound of the following formula (I) for preparing 4-( 10 B)borono-L-phenylalnine: wherein R group represents a protecting group and is selected from the group consisting of:tert-butoxycarbonyl (t-Boc) group, trityl (Trt) group, 3,5-dimethoxyphenylisopropoxycarbonyl (Ddz) group, 2-(4-Biphenyl)isopropoxycarbonyl (Bpoc) group, and 2-nitrophenylsulfenyl (Nps) group, and the compound has a 10 B purity higher than or equal to 98 % and an enantiomeric excess higher than or equal to 99%. |
