| 摘要 |
FIELD: medicine, pharmaceutics.SUBSTANCE: invention relates to field of organic chemistry, namely to heterocyclic compound of general formula (I) or to its pharmaceutically acceptable salt, acid salt or stereoisomer, where Y: NRand NRRX; Z: bond, -(CH), -CHOH, -CH=CH-, -C?C-, -CONH- and -CO-; R: C-Calkyl, C-Calkenyl, C-Caryl, -NRR,:, and; with each alkyl, alkenyl and aryl, representing R, possibly, contains 1-3 substituents, selected from C-Calkyl, C-Calkenyl, C-Ccycloalkyl, C-Calkoxy, C-Caryl, 5-, 6- and 7-membered heterocyclyl, containing 1-3 heteroatoms, selected from nitrogen, oxygen and sulphur, halogen, -OH, -NH, -CN and -NO; R: halogen, C-Calkyl, C-Calkenyl, C-Calkinyl, C-Ccycloalkyl, C-Ccycloalkenyl, C-Calkoxy, C-Caryl, 5-, 6-, 7- and 8-membered monocyclic heterocyclyl, containing 1-3 heteroatoms, selected from nitrogen, oxygen and sulphur, 9- and 10-membered bicyclic heterocyclyl, containing 1-3 heteroatoms, selected from nitrogen, oxygen and sulphur; with C-Calkyl, C-Calkenyl C-Calkinyl, C-Ccycloalkyl, C-Ccycloalkenyl, C-Caryl, 5-, 6-, 7-, 8-membered monocyclic heterocyclyl and 9- and 10-membered bicyclic heterocyclyl, representing R, possibly contain 1-5 substituents, selected from the group, consisting of C-Calkyl, C-Calkoxy, C-Chaloalkyl, C-Chaloalkoxy, C-Ccycloalkyl, C-Ccycloalkenyla, halogen, -OH, -NH, C-C(A)(A')(A")(A'")aryl, (A)(A')(A")(A'")heterocyclyl, containing 1-3 heteroatom, selected from nitrogen, oxygen and sulphur, NRR, (CH)NRR, -CN, -NO, oxo, -COOR, SOR, SOR, SONRR, NRSOR, COR, CONRRand NRCOR; with each (A), (A'), (A") and (A'")independently absent or representing C-Calkyl, and each heterocyclyl (A)(A')(A")(A'")heterocyclyl is independently selected from the group, consisting of 5-, 6-, 7- and 8-membered monocyclic heterocyclyl, containing 1-3 heteroatoms, selected from nitrogen, oxygen and sulphur, and 9- and 10-membered bicyclico heterocyclyl, containing 1-3 heteroatoms, selected from nitrogen, oxygen and sulphur; the remaining radicals have values given in i.1;and on condition that, if Rrepresents heterocyclyl, said heterocyclyl is bound directly through carbon atom of heterocyclyl ring. Invention also relates to particular compounds and to pharmaceutical composition based on formula (I) compound.EFFECT: obtained are novel imidazopyrazine and imidazodiazepine derivatives, useful for prevention or treatment of disease or condition, severity of which is reduced by receptors to cannabinoids.21 cl, 5 dwg, 4 tbl, 71 ex |
