发明名称 |
PERFORMING CHEMICAL REACTIONS AND/OR IONIZATION DURING GAS CHROMATOGRAPHY-MASS SPECTROMETRY RUNS |
摘要 |
A gas chromatography-mass spectrometry (GC-MS) method that includes performing a first GC-MS run on a sample using a gas chromatography-mass spectrometry system. Performing the first GC-MS nm includes i) passing a first flow of a carrier gas carrying a first portion of the sample through a gas chromatograph to provide a first effluent; ii) generating first ions under protonation conditions by passing the first effluent through an atmospheric pressure ionization source; iii) passing the first ions through a mass spectrometer; and iv) recording first GC-MS data for the first ions. The method also include performing a second GC-MS run on the sample using the gas chromatography-mass spectrometry system. |
申请公布号 |
US2015024510(A1) |
申请公布日期 |
2015.01.22 |
申请号 |
US201314376862 |
申请日期 |
2013.01.30 |
申请人 |
Waters Technologies Corporation |
发明人 |
Stevens Douglas M. |
分类号 |
G01N27/62 |
主分类号 |
G01N27/62 |
代理机构 |
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代理人 |
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主权项 |
1. A gas chromatography-mass spectrometry (GC-MS) method comprising:
A) performing a first GC-MS run on a sample using a gas chromatography-mass spectrometry system, comprising:
i) passing a first flow of a carrier gas carrying a first portion of the sample through a gas chromatograph to provide a first effluent;ii) generating first ions under protonation conditions by passing the first effluent through an atmospheric pressure ionization source;iii) passing the first ions through a mass spectrometer; andiv) recording first GC-MS data for the first ions; and B) performing a second GC-MS run on the sample using the gas chromatography-mass spectrometry system, comprising:
i) passing a second flow of the carrier gas carrying a second portion of the sample through the gas chromatograph to provide a second effluent;ii) generating second ions under deuteration conditions by passing the second effluent through the atmospheric pressure ionization source;iii) passing the second ions through a mass spectrometer; andiv) recording second GC-MS data for the first ions; and C) comparing the first and second GC-MS data to assess the presence of one or more compounds in the sample that ionize by hydride abstraction. |
地址 |
Milford MA US |