FOLATE RECEPTOR ALPHA BINDING LIGANDS

摘要

The invention described herein pertains to targeted drug delivery conjugates comprising folate receptor α (FR-α) selective binding ligands and methods for diagnosing, monitoring, and eliminating pathological cells that express FR-α.

主权项

1. A folate receptor alpha selective binding ligand drug conjugate of the formula
B-L-D or a pharmaceutically acceptable salt thereof, wherein
B is a folate receptor alpha selective binding ligand;L is a linker or is absent; andD represents one or more drugs each independently selected from the group consisting of a diagnostic agent, a therapeutic agent, and an imaging agent.