发明名称 |
Polyvinylpyrrolidone for the stabilization of a solid dispersion of the non-crystalline form of rotigotine |
摘要 |
<p>The present invention relates to a method for stabilizing rotigotine, the method comprising providing a solid dispersion comprising polyvinylpyrrolidone and a non-crystalline form of rotigotine, wherein the weight ratio of rotigotine to polyvinylpyrrolidone is in a range from about 9:3.5 to about 9:6. The present invention also relates to a solid dispersion comprising a dispersing agent and a dispersed phase, said dispersed phase comprising rotigotine and polyvinylpyrrolidone, wherein the weight ratio of rotigotine to polyvinylpyrrolidone is in a range from about 9:3.5 to about 9:6, a pharmaceutical composition comprising such a solid dispersion, in particular a transdermal therapeutic system, as well as a method for the preparation thereof.</p> |
申请公布号 |
AU2010334805(B2) |
申请公布日期 |
2015.01.22 |
申请号 |
AU20100334805 |
申请日期 |
2010.12.22 |
申请人 |
LTS LOHMANN THERAPIE-SYSTEME AG;UCB PHARMA GMBH |
发明人 |
WOLFF, HANS-MICHAEL;ARTH, CHRISTOPH;QUERE, LUC;MULLER, WALTER |
分类号 |
A61K9/70;A61K31/381 |
主分类号 |
A61K9/70 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|