| 主权项 |
1. Compounds of the formula I R1 denotes Ar1, Carb, Het1 or H, R2 denotes Are, Carb, Cyc, Het2, NR3(CH2)nHet2, NR3Cyc, N(R3)2, NR3(CH2)pN(R3)2, NR3(CH2)pNR3COA, NR3SO2A, NR3SO2Ar3, NR3SO2Het3, O(CH2)nHet3 or NR3Ar3, Ar1 denotes phenyl, which is mono-, di- or trisubstituted by A, (CH2)nOH, (CH2)nOA, (CH2)nHet3, CN, SO2NH2, SO2CH3, SOCH3, Cyc, (CH2)nNH2, (CH2)nNHA, (CH2)nNA2 and/or (CH2)nSO3H, Ar2 denotes phenyl or biphenyl, which is unsubstituted or mono-, di- or trisubstituted by Hal, CN, (CH2)nOH, (CH2)nOA, NHSO2A, (CH2)nHet3, [C(R3)2]nNH2, [C(R3)2]nNHA, [C(R3)2]nNA2, SO2CH3, SO2NH2 and/or COHet3, Het1 denotes pyridyl, benzimidazolyl, benzotriazolyl, indolyl, indazolyl, benzo[1,4]oxazinyl, 1,3- or 2,3-dihydro-indolyl, benzothiadiazolyl, 1,2,3,4-tetrahydro-quinolyl, spiro(cyclobutan-1,3′-indolyl), spiro(cyclobutan-1,3′-indolinyl), 1,4-dihydro-benzo[d][1,3]oxazinyl, 3,4-dihydro-1H-quinolyl, 3,4-dihydro-1H-quinozalinyl, chromanyl, [1,2,4]triazolo[4,3-a]pyridyl, 1,2,3,4-tetrahydro-quinoxalinyl or 2,3-dihydro-1H2l6-benzo[c]isothiazolyl, each of which is unsubstituted or mono-, di-, tri- or tetrasubstituted A, OH, OA, SO2NH2, (CH2)nNH2, (CH2)nNHA, (CH2)nNA2, Hal and/or ═O, Het2 denotes piperidinyl, piperazinyl, pyrrolidinyl, morpholinyl, tetrahydropyranyl, pyrazolyl, indazolyl, azetidinyl, pyridyl, isoxazolyl, pyrimidinyl, furyl, thienyl, pyrido[2,3-b]pyrazinyl, 2-oxa-6-aza-spiro[3,4]octyl, 2,5-diaza-bicyclo[2.2.1]heptyl, 1,4-dioxa-7-aza-spiro[4.4]nonyl, 7,8-dihydro-5H-pyrido[4,3-d]pyrimidinyl, 1,3,7-triaza-spiro[4.5]-decyl, 2,5,7-triaza-spiro[3.4]octyl, 1,3,7-triaza-spiro[4.4]nonyl, 2-oxa-6-aza-spiro[3.3]heptyl, 2-oxa-6-aza-spiro[3.5]nonyl, 2,7-diaza-spiro[4.4]nonyl, 2,8-diaza-spiro[4.5]decyl, 3-oxa-8-aza-bicyclo[3.2.1]octyl, 1,4,6,7-tetrahydro-imidazo[4,5-c]pyridinyl, 4,5,6,7-tetrahydro-pyrazolo[1,5-a]pyrazinyl, 1,2,3,4-tetrahydro-quinolyl, quinolyl, indazolyl, diazepanyl, azepanyl, 2-oxa-3,9-diaza-spiro[5.5]undecenyl, triazolyl, 8-oxa-3-aza-bicyclo[3.2.1]octyl, 1,3,8-triaza-spiro[4.5]decenyl, 1-oxa-3,7- or 3,8-diaza-spiro[4.5]decyl, 1,3,8-triaza-spiro[4.5]decyl, 4,6-dihydro-1H-pyrrolo[3,4-c]pyrazolyl, hexahydro-pyrazino[1,2-a]pyrazinyl, tetrahydro-benzo[b]azepanyl, 2,3-dihydro-benzo[1,4]dioxinyl, 2,3-dihydro-indolyl, indolyl, 8-aza-bicyclo[3.2.1]octyl, 3,4-dihydro-2H-quinolyl, 3,4-dihydro-2H-pyrano[2,3-b]pyridyl, [1,2,4]triazolo[1,5-a]pyrazinyl, spiro[indole-3,3′-pyrrolidinyl], 6-oxa-2,9-diaza-spiro[4,5]decyl, tetrahydro-pyrrolo[3,4-c]pyrrolyl, 1,8-diaza-spiro[4.5]decyl, 1,2,3,4-tetrahydro-isoquinolyl, 6,7-dihydro-4H-pyrazolo[5,1-c][1,4]oxazinyl, 1-aza-bicyclo[2.2.2]octyl, octahydro-isoquinolyl or 3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazinyl, each of which is unsubstituted or mono-, di- or trisubstituted by Hal, A, (CH2)nNH2, (CH2)nNHA, (CH2)nNA2, (CH2)—OH, (CH2)nOA, (CH2)—Ar3, (CH2)nHet3, SO2A, SO2A, NHCOA, NACOA, NHSO2A, NASO2A, COOA, CONH2, COA, CONHA, COOH, SO2NH2, SO2NHA, SO2NA2, (CH2)—OCHO, NH(CH2)nHet3, CN and/or ═O, Het3 denotes piperidinyl, piperazinyl, pyrrolidinyl, morpholinyl, imidazolidinyl, tetrahydro-pyranyl, imidazolyl or indolinyl, each of which is unsubstituted or mono-, di- or trisubstituted by A and/or ═O, R3 denotes H or alkyl having 1, 2, 3 or 4 C-atoms, A denotes unbranched or branched alkyl having 1-10 C atoms, in which 1-7H atoms may be replaced by F and/or in which one or two non-adjacent CH2 groups may be replaced by O and/or NH, or
cyclic alkyl having 3-7 C atoms, Cyc denotes cyclic alkyl having 3-7 C atoms, which is unsubstituted or monosubstituted by NH2, CN, CONH2 or OH, Ar3 denotes phenyl, which is unsubstituted or mono- or disubstituted by F, A, CN, NH2, NHA, NA2 and/or CONH2, Carb denotes indanyl or 5,6,7,8-tetrahydro-naphthyl, which is unsubstituted or mono-, di-, tri- or tetrasubstituted by A, Hal denotes F, Cl, Br or I, n denotes 0, 1, 2, 3 or 4, p denotes 1, 2, 3 or 4,
and pharmaceutically acceptable solvates, salts, tautomers and stereoisomers thereof, including mixtures thereof in all ratios. |
