PHARMACEUTICAL COMPOSITIONS FOR PREVENTING OR TREATING ANGIOGENIC DISEASES COMPRISING INHIBITORS OF NUP153 GENE EXPRESSION OR NUP153 ACTIVITY AS ACTIVE INGREDIENT

摘要

The present invention provides a pharmaceutical composition for preventing or treating angiogenic diseases comprising inhibitors of NUP153 gene expression or NUP153 activity as active ingredient and a method for screening an agent for preventing or treating angiogenic diseases. According to the present invention, inhibition of the NUP153 gene expression or the NUP153 activity reduces export of mRNA of a pro-angiogenic factor (VEGF, HGF and bFGF) from nucleus. In addition, inhibition of the NUP153 gene expression or the NUP153 activity has effect that angiogenesis are inhibited by inhibition of invasion and tube formation in a dose-dependent manner without showing toxicity. Therefore, the pharmaceutical composition of the present invention may be used for preventing or treating a variety of angiogenesis-related diseases, and the method for screening of the present invention may be valuably used in finding a new agent for preventing or treating angiogenic diseases.

主权项

1. A method for screening an agent for preventing or treating angiogenic diseases comprising:
contacting a test material with a cell comprising NUP153 gene or NUP153; and measuring an amount of NUP153 gene expression or NUP153, or an activity of NUP153; Wherein, where down-regulation of the amount of NUP153 gene expression or NUP153, or the activity of NUP153 is observed compared to a non-treatment of the test material, the test material is determined as an agent for preventing or treating angiogenic diseases.