(HETERO)ARYL CYCLOPROPYLAMINE COMPOUNDS AS LSD1 INHIBITORS

摘要

The invention relates to (hetero)aryl cyclopropylamine compounds, including particularly the compounds of formula I as described and defined herein, and their use in therapy, including, e.g., in the treatment or prevention of cancer, a neurological disease or condition, or a viral infection.;

主权项

1. A pharmaceutical composition comprising a compound of Formula I wherein: A is aryl or heteroaryl, wherein said aryl or heteroaryl is optionally substituted with one or more R1; B is H, R1 or -L1-E; E is aryl or heteroaryl, wherein said aryl or said heteroaryl is optionally substituted with one or more R2; L1 is a bond, —O—, —NH—, —N(C1-4 alkyl)-, alkylene or heteroC1-4alkylene; L2 is a bond and D is a cyclic group selected from:
(i) a 3- to 7-membered monocyclic saturated heterocyclic ring containing 1 or 2 heteroatoms independently selected from N, O and S, and(ii) a 7- to 15-membered polycyclic ring system which comprises at least one saturated heterocyclic ring, wherein the polycyclic ring system contains from 1 to 4 heteroatoms independently selected from N, O and S,wherein the cyclic group (i) or (ii) is linked to the remainder of the compound of Formula I through a ring C atom,wherein one or more ring C atoms in the cyclic group (i) or (ii) are optionally oxidized to form CO groups,wherein one or more S atoms in the cyclic group (i) or (ii), if present, are optionally oxidized to form independently SO groups or SO2 groups, and wherein the cyclic group (i) or (ii) is optionally substituted with one or more R3; each R1 is independently selected from C1-8 alkyl, C2-8 alkenyl, C2-8, alkynyl, cyclyl, amino, amido, hydroxyl, nitro, halo, haloC1-8 alkyl, haloC1-8 alkoxy, cyano, sulfinyl, sulfonyl, sulfonamide, C1-8 alkoxy, acyl, carboxyl, O-carboxy, C-carboxy, carbamate and urea; each R2 is independently selected from C1-8 alkyl, C2-8 alkenyl, C2-8 alkynyl, cyclyl, amino, amido, hydroxyl, nitro, halo, haloC1-8 alkyl, haloC1-8 alkoxy, cyano, sulfinyl, sulfonyl, sulfonamide, C1-8 alkoxy, acyl, carboxyl, O-carboxy, C-carboxy, carbamate and urea; each R3 is independently selected from C1-8 alkyl, C2-8 alkenyl, C2-8 alkynyl, cyclyl, amino, amido, hydroxyl, nitro, halo, haloC1-8 alkyl, haloC1-8 alkoxy, cyano, sulfinyl, sulfonyl, sulfonamide, C1-8 alkoxy, acyl, carboxyl, O-carboxy, C-carboxy, carbamate and urea; and each Rw, Rx, Ry and Rz is independently selected from hydrogen, halo and C1-4 alkyl; or a salt or solvate thereof, and a pharmaceutical acceptable carrier.