SELF-REGULATED PEPTIDE HYDROGEL FOR INSULIN DELIVERY

摘要

A glucose binding amphiphilic peptide hydrogel insulin delivery system that is responsive to glucose concentrations under physiological conditions is provided. Insulin is encapsulated in a glucose binding hydrogel, made from self-assembling amphiphilic peptides including a hydrophobic domain including a beta sheet forming region coupled to a charged hydrophilic domain modified to contain a glucose binding segment. The formulations are designed to release insulin as a function of blood glucose level, maintaining the patients' blood glucose level in an optimum range and avoiding both hyper- and hypoglycemia.

主权项

1. A self-assembling glucose binding peptide comprising:
(a) a hydrophilic region comprising a charged segment which enhances solubility of the peptide in an aqueous environment and a glucose binding moiety, (b) a hydrophobic region, and (c) a beta-sheet forming region, wherein the charged hydrophilic and hydrophilic domains are covalently linked via the beta-sheet forming segment and self-assemble under physiological conditions to form a hydrogel and wherein binding of glucose to the glucose binding moiety increases the permeability of the hydrogel.