摘要 |
The present invention provides methods for the identification, isolation and/or enrichment of human corneal endothelial cells (HCECs). In some embodiments, the method comprises a positive selection process in which a cell population containing human corneal cells is contacted with a positive affinity reagent that selectively binds to HCECs relative to cells other than HCECs (e.g., corneal keratocytes, etc.) in the population and/or a negative selection process in which a cell population containing HCECs is contacted with a negative affinity reagent that selectively binds to cells other than HCECs in the population relative to HCECs. The present invention also provides reagents and kits for the identification, isolation and/or enrichment of HCECs as well as compositions that are enriched in HCECs. |
申请人 |
EMMETROPE OPHTHALMICS LLC;GOLDBERG, JEFFREY, L.;KUNZEVITZKY, NOELIA, J. |
发明人 |
GOLDBERG, JEFFREY, L.;KUNZEVITZKY, NOELIA, J. |