| 主权项 |
1. A compound of formula I: or a pharmaceutically acceptable salt thereof; wherein: X is N or CH; m and n are each independently 1, 2 or 3; p and q are each independently 0 or 1; D is a bond, —C(O)—, —C(O)NRb—, —C(O)O— or —SO2—; R1 and R2 are independently H, halogen or C1-3alkyl; R3 is selected from the group consisting of (1) hydrogen, (2) C1-6alkyl, (3) C2-10alkenyl, (4) C2-10alkynyl, (5) -L-C3-10cycloalkyl, (6) -L-aryl, (7) -L-heteroaryl, (8) -L-heterocyclyl, wherein alkyl, alkenyl and alkynyl are optionally substituted with 1 to 5 groups independently selected from Rx; cycloalkyl and heterocyclyl are optionally substituted with 1 to 5 groups independently selected from Ry; and aryl and heteroaryl are optionally substituted with 1 to 5 groups independently selected from Rz; L is a bond, C1-6alkylene, C2-6alkenylene, C2-6alkynylene, arylene, heteroarylene, C3-10cycloalkylene or heterocyclyene; wherein alkylene, alkenylene and alkynylene are optionally substituted with 1 to 5 groups independently selected from Rx, aryl and heteroaryl wherein aryl and heteroaryl are optionally substituted with 1 to 3 groups independently selected from Rz; cycloalkylene or heterocyclyene are optionally substituted with 1 to 5 groups independently selected from Ry; and arylene and heteroarylene are optionally substituted with 1 to 5 groups independently selected from Rz; R4a, R4b, R5a and R5b and are each independently selected from the group consisting of (1) hydrogen, (2) ORa, (3) cyano, (4) halogen, (5) C1-6alkyl, (6) C2-10alkenyl, (7) C(O)Ra, (8) CO2Ra, (9) NRbRc, and (10) CONRbRc, wherein alkyl, alkenyl and alkylcarbonyl are optionally substituted with 1 to 5 groups independently selected from Rx; R6 is H or NHRb; Ra is selected from the group consisting of H, C1-6alkyl, C1-6haloalkyl, C2-6hydroxyalkyl, C2-6(C1-3alkoxy)alkyl, C2-6cyanoalkyl, C2-6aminoalkyl, C2-6(monoC1-3alkylamino)alkyl, C2-6(diC1-3alkylamino)alkyl, C3-6cycloalkyl, aryl, heteroaryl and heterocyclyl; Rband Rcare each independently selected from H, C1-6alkyl, C1-6haloalkyl, C3-6cycloalkyl, C2-6cyanoalkyl, C2-6hydroxyalkyl, C2-6aminoalkyl, —CORa, aryl and heteroaryl; or Rb, Rcand the nitrogen atom to which they are attached together form a 4- to 7-membered ring optionally having an additional heteroatom selected from NRd, O and S(O)r, wherein said ring being optionally substituted with 1 to 4 groups independently selected from halogen, cyano and C1-6cyanoalkyl; r is 0, 1 or 2, Rd is selected from the group consisting of (1) H, (2) C1-6alkyl, (3) C(O)C1-6alkyl, Rx is selected from the group consisting of (1) oxo, (2) ORa, (3) cyano, (4) halogen, (5) NRbRc, (6) CO2Ra, (7) CONRbRc; (8) —CORa, (9) —C0-6alkylaryl, (10) —C0-6alkylheteroaryl, and (11) S(O)rRa; Ry is selected from the group consisting of (1) a member of Rz, and (2) oxo; Rz is selected from the group consisting of (1) ORa, (2) cyano, (3) halogen, (4) CORa, (5) CO2Ra, (6) nitro, (7) NRbRc, and (8) CONRbRc; (9) C1-6alkyl, (10) C1-6haloalkyl, (11) C1-6hydroxyalkyl, (12) C1-6cyanoalkyl, (13) C1-6(C1-3alkoxy)alkyl, (14) C1-6aminoalkyl, (15) C1-6 mono(C1-3alkylamino)alkyl, (16) C1-6di(C1-3alkylamino)alkyl, (17) C2-6alkenyl, (18) C2-6alkynyl, (19) —SO2NRbRc, (20) —NRbSO2C1-6alkyl, (21) —NRbSO2aryl (22) —C0-6alkylNC(O)(OC1-6 alkyl). |
