| 发明名称 | Polyethyleneglycol-modified lipid compounds and uses thereof | ||
| 摘要 | The present invention provides compositions comprising polytheylyene-dialkyloxypropyl conjugates (PEG-DAA), liposomes, SNALP, and SPLP comprising such compositions, and methods of using such compositions, liposomes, SNALP, and SPLP. | ||
| 申请公布号 | US8936942(B2) | 申请公布日期 | 2015.01.20 |
| 申请号 | US201012852362 | 申请日期 | 2010.08.06 |
| 申请人 | Protiva Biotherapeutics, Inc. | 发明人 | Heyes James;MacLachlan Ian;Ambegia Ellen Grace |
| 分类号 | A61K31/713;A61K48/00;A61K9/127;C12N15/88;A61K31/7088;A61K31/7105;A61K47/18;A61K47/24;A61K47/48;C07C233/18;C07C235/08;C07C271/16 | 主分类号 | A61K31/713 |
| 代理机构 | Kilpatrick Townsend & Stockton LLP | 代理人 | Kilpatrick Townsend & Stockton LLP |
| 主权项 | 1. A liposome, said liposome comprising a polyethyleneglycol-dialkyloxypropyl (PEG-DAA) conjugate of Formula I having the following structure:wherein: Rl and R2 are independently selected and are alkyl groups having from about 10 to about 20 carbon atoms; PEG is a polyethyleneglycol, wherein the terminal hydroxyl group is substituted with a methyl group; and L is a non-ester containing linker moiety. | ||
| 地址 | Burnaby CA | ||