LIVER CANCER RELATED GENES-SPECIFIC SIRNA, DOUBLE-STRANDED OLIGO RNA MOLECULES COMPRISING THE SIRNA, AND COMPOSITION FOR THE PREVENTION OR TREATMENT OF CANCER COMPRISING THE SAME

摘要

The present invention relates to siRNA specific to gene related to liver cancer, and to a double-stranded oligo RNA structure including the same with high efficiency. The double-stranded oligo RNA structure includes a hydrophilic substance and a hydrophobic substance bound by simple covalent bonds or linker-mediated covalent bonds on both ends thereof. Therefore, the double-stranded oligo RNA structure can be efficiently transported into a cell. The double-stranded oligo RNA structures can be transformed into nanoparticles by a hydrophobic interaction thereof in an aqueous solution. The siRNA included in the double-stranded oligo RNA structures is desirably specific to a gene related to liver cancer which particularly is ZBTB7A, YAP1, or CHD1L. Moreover, the present invention relates to a method for producing the double-stranded oligo RNA structure, and to a pharmaceutical composition including the double-stranded oligo RNA structure for preventing or treating cancer, particularly liver cancer.