| 发明名称 |
Preparation of Triple Responsive Nanogel System and its Application |
| 摘要 |
A thermal triple-responsive polymer, along with methods of its formation and use, is generally provided. The thermal triple-responsive polymer can comprise poly[(2-(pyridin-2-yldisulfanyl)-co-[poly(ethylene glycol)]-co-[N-isopropyl methacrylamide], which contains both disulfide bonds and ester bonds that are labile to high redox potential and acidic pH, respectively, and temperature sensitive segments. The thermal triple-responsive polymer can be modified with 4-methoxybenzoic acid to endow tumor targeting effect. Nanoparticles and nanogels that include such a thermal triple-responsive polymer are also provided, along with their methods of formation and use. |
| 申请公布号 |
US2015018308(A1) |
申请公布日期 |
2015.01.15 |
| 申请号 |
US201414330336 |
申请日期 |
2014.07.14 |
| 申请人 |
Xu Peisheng;He Huacheng |
发明人 |
Xu Peisheng;He Huacheng |
| 分类号 |
A61K47/32;C08F220/68;A61K41/00;A61K31/695 |
主分类号 |
A61K47/32 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A thermal triple-responsive polymer, comprising: poly[(2-(pyridin-2-yldisulfanyl)-co-[poly(ethylene glycol)]-co-[N-isopropyl methacrylamide], which contains both disulfide bonds and ester bonds that are labile to high redox potential and acidic pH, respectively, and temperature sensitive segments. |
| 地址 |
Chapin SC US |
